Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Biological goals and you can pharmacology away from curcumin
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin is the major element of the reddish dye of turmeric, a keen Indian spice that is extracted from the brand new rhizome of your tropical bush Curcuma longa, which belongs to the Zingiberaceae family members. Within section, we talk about the pharmacological things off curcumin and you may speak about the fresh molecular angles of these items. I upcoming remark new confirmed and you will potential logical uses out of curcumin. Curcumin is well known historically just like the a curative agent, however, its system regarding action is actually outlined. The pharmacological results of curcumin be seemingly the result of a great synergism away from channels away from weak biochemical connections which have multiple physical targets from inside the interconnected signaling paths. Such goals tend to be minerals including cyclooxygenase, lipoxygenase and you will healthy protein kinases, and you will transcription items for example NF-?B, STAT and Nrf2. Modulation of these particles has an effect on downstream affectors that produce brand new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and antimicrobial activities out-of curcumin. These consequences had been checked out inside logical trials off curcumin to own aches and inflammatory disorder, disease, Alzheimer state, cardio ailment, and you can diabetic issues. The latest samples have tried adjustable doses out of curcuminwith different frequencies and you may period, towards general end one to highest dosage regarding curcumin at the amount of g have to see healing consequences. Find out more
Curcumin: Synthesis, Emerging Role inside Problems Management and Wellness Effects
Book Section Samples of plant-derived pharmaceuticals with become the notice away from continuing and you can great search and you can innovation focus possess, thus far, become somewhat scarce. Just after several years, the very last 2 decades was basically described as a good 100-flex upsurge in the amount of scientific posts wrote a year one try out of importance with the use of curcumin in the biomedicine. Read more
Build, synthesis and you will physical facts out of curcumin prodrugs
Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has many potential pharmacological outcomes and will keeps therapeutic applications in hyperlinkki several state says, since chatted about in more detail in the last part. But not, the possibility scientific efficacy off curcumin is restricted by the physicochemical services of poor h2o solubility and you will instability, and that produce lower bioavailability. Prodrugs of curcumin render an approach to upgrade of one’s biopharmaceutical and you may pharmacokinetic functions, that can create exploitation of your own pharmacological ramifications of curcumin. Within part, we first comment the latest physicochemical and you will pharmacokinetics off curcumin. We following establish the design of curcumin prodrugs having increased drinking water solubility and increased toxins balance that can be translated to free curcumin through to bioactivation into the vivo. We focus on present achievements here, which have a concentrate on the build, synthesis and evaluation of prodrugs centered on promoieties as well as amino acids, efas, nucleic acids, dicarboxylic acids, and you will polymeric materials such as for example hyaluronic acidic and you can polyethylene glycol. That it part contains the basis for optimization of your own physicochemical and you will biopharmaceutical properties additionally the biological issues off curcumin prodrugs, towards the objective playing with of those curcumin derivatives inside scientific software. Find out more